34 research outputs found

    Coherent Detector Arrays for Millimeter and Submillimeter Astronomy

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    Progress in many areas of astronomy requires large-area surveys and observations of extended objects. This includes the cosmic microwave background, nearby galaxies, the Milky Way, and regions of star-forming regions within our galaxy. The ability to carry out such studies is critically dependent on the development of affordable high-sensitivity focal plane arrays, for both spectral line and continuum observations. We discuss a program for the next decade to develop such technology for ground-based and spacebased millimeter and submillimeter astronomy. Appropriate technologies exist, but significant effort is required to make the transition from simply replicating individual pixels to approaching focal plane array design in an integrated fashion from feeds to spectrometers for spectral analysis. This advance is essential to realize the full potential of major new ground-based, suborbital, and future space facilities, and is relevant to the RMS and EOS panels. The recommended budget for this activity is $65M

    A Second-Generation Device for Automated Training and Quantitative Behavior Analyses of Molecularly-Tractable Model Organisms

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    A deep understanding of cognitive processes requires functional, quantitative analyses of the steps leading from genetics and the development of nervous system structure to behavior. Molecularly-tractable model systems such as Xenopus laevis and planaria offer an unprecedented opportunity to dissect the mechanisms determining the complex structure of the brain and CNS. A standardized platform that facilitated quantitative analysis of behavior would make a significant impact on evolutionary ethology, neuropharmacology, and cognitive science. While some animal tracking systems exist, the available systems do not allow automated training (feedback to individual subjects in real time, which is necessary for operant conditioning assays). The lack of standardization in the field, and the numerous technical challenges that face the development of a versatile system with the necessary capabilities, comprise a significant barrier keeping molecular developmental biology labs from integrating behavior analysis endpoints into their pharmacological and genetic perturbations. Here we report the development of a second-generation system that is a highly flexible, powerful machine vision and environmental control platform. In order to enable multidisciplinary studies aimed at understanding the roles of genes in brain function and behavior, and aid other laboratories that do not have the facilities to undergo complex engineering development, we describe the device and the problems that it overcomes. We also present sample data using frog tadpoles and flatworms to illustrate its use. Having solved significant engineering challenges in its construction, the resulting design is a relatively inexpensive instrument of wide relevance for several fields, and will accelerate interdisciplinary discovery in pharmacology, neurobiology, regenerative medicine, and cognitive science

    Working with others : Mediating research and practice in participatory video

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    In this paper, we explore the boundary between the different communities of practice typically involved in a participatory video (PV) initiative. In particular, we are interested to pay attention to the experience of participatory video practitioners as they engage with researchers. From the viewpoint of organizing practice, what does working with researchers bring to PV? What disciplines and commitments does this other tribe offer? Does it matter that we use different languages to describe what we’re doing, and when might it be more fruitful to let go of comprehensive mutual understanding and learn just to go with the flow? Based on 14 years of collaboration, we invite discussion on how to make working together rewarding and productive.

    Working with others : Mediating research and practice in participatory video

    No full text
    In this paper, we explore the boundary between the different communities of practice typically involved in a participatory video (PV) initiative. In particular, we are interested to pay attention to the experience of participatory video practitioners as they engage with researchers. From the viewpoint of organizing practice, what does working with researchers bring to PV? What disciplines and commitments does this other tribe offer? Does it matter that we use different languages to describe what we’re doing, and when might it be more fruitful to let go of comprehensive mutual understanding and learn just to go with the flow? Based on 14 years of collaboration, we invite discussion on how to make working together rewarding and productive.

    Phenolic compounds, antioxidant and anti-cancer properties of the Australian Maroon Bush Scaevola spinescens (Goodeniaceae)

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    Scaevola spinescens (Goodeniaceae) has been traditionally used by indigenous Australians to treat various ailments including cancer, thus it is necessary to identify optimum extraction conditions for bioactive components from this plant. This study investigated the effects of different extraction conditions on Total Phenolic Content (TPC), antioxidant capacity (ABTS, DPPH, CUPRAC, FRAP assays) and anti-cancer activity (MTT assay) of S. spinescens. The results showed that optimal extraction conditions for TPC using water were 80°C, 15 min and ratio of 20:1 mL/g. However, the aqueous extract prepared under optimal conditions had lower TPC and less antioxidant capacity than those of the organic solvent extracts. The acetone extract displayed the greatest TPC as well as the highest antioxidant capacity and anti-cancer activity against a panel of cancer cell lines, including cancers of the pancreas, breast, lung, brain, skin, colon and ovary. Therefore, further investigations should be conducted to identify key bioactive compounds as potential anti-cancer agents
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